This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison
Homologies
DNA
Below is the gene tree of the DNA sequence of FMR1. Highlighted are the homologs presented above, minus Danio rerio. As can be seen as you move down the phylogeny trees the pattern of relationships between the animals is conserved until you reach the protein tree. The protein tree might have a slightly different tree because of post-translational modifications that each animal uses for a different function of the protien. As seen in both the mRNA and Protein trees, located further down the page, Danio rerio is earliest splitting from the main group which might be why it isnt present in the long list of the DNA homologs.
mRNA
Muscle alignment, maximum likelyhood, gap positions in the sequences were removed for the final alignment.
Protein Homologs
Pan troglodytes: NC_006491.2
Fragile X mental retardation 1 protein
Size in amino acids: 920
Identity 99.6%
Protein accession number: XP_521294
Identity 99.8%
Fragile X mental retardation 1 protein
Size in amino acids: 920
Identity 99.6%
Protein accession number: XP_521294
Identity 99.8%
Mus musculus: NC_000086.6
Fragile X mental retardation syndrome 1 homolog
Size in amino acids: 614
Identity: 95.1%
Protein accession number: NP_032057.2
Identity: 96.9%
Fragile X mental retardation syndrome 1 homolog
Size in amino acids: 614
Identity: 95.1%
Protein accession number: NP_032057.2
Identity: 96.9%
Rattus norvegicus: NC_005120.2
Fragile X mental retardation syndrome 1 homolog
Size in amino acids: 581
Identity: 94.7%
Protein accession number: NP_434691.1
Identity: 97.2%
Fragile X mental retardation syndrome 1 homolog
Size in amino acids: 581
Identity: 94.7%
Protein accession number: NP_434691.1
Identity: 97.2%
Canis familiaris: NC_006621.2
Fragile X mental retardation 1 protein
Size in amino acids: 632
Identity: 95.8%
Protein accession number: XP_866618.1
Identity: 97.5%
Fragile X mental retardation 1 protein
Size in amino acids: 632
Identity: 95.8%
Protein accession number: XP_866618.1
Identity: 97.5%
Bos taurus: NC_007331.3
Hypothetical protein
Size in amino acids: 632
Identity: 94.8%
Protein accession number: XP_584993.4
Identity: 96.2%
Hypothetical protein
Size in amino acids: 632
Identity: 94.8%
Protein accession number: XP_584993.4
Identity: 96.2%
Gallus gallus: NC_006091.2
Hypothetical protein
Size in amino acids: 565
Identity: 83.9%
Protein accession number: XP_420363.1
Identity: 89.1%
Hypothetical protein
Size in amino acids: 565
Identity: 83.9%
Protein accession number: XP_420363.1
Identity: 89.1%
Danio rerio: NC_007125.3
Fragile X mental retardation 1
Size in amino acids: 569
Identity: 74.6%
Protein accession number: NP_694495.1
Identity: 80.0%
Fragile X mental retardation 1
Size in amino acids: 569
Identity: 74.6%
Protein accession number: NP_694495.1
Identity: 80.0%
Below is a condensed list of the FASTA data for the gene homologies. From http://www.ncbi.nlm.nih.gov/homologene
homologene.txt | |
File Size: | 378 kb |
File Type: | txt |
Protien
Muscle alignment, maximum likelyhood, gap positions in the sequences were removed for the final alignment.
References
[1] DNA gene tree figure taken from Ensembl: http://oct2007.archive.ensembl.org/Homo_sapiens/genetreeview?gene=ENSG00000102081
[2] Clustal: http://www.phylogeny.fr
[3] Homologene: http://www.ncbi.nlm.nih.gov/homologene/1531
[2] Clustal: http://www.phylogeny.fr
[3] Homologene: http://www.ncbi.nlm.nih.gov/homologene/1531
Aime Agather
[email protected]
Last Updated 03/28/2010
Genetics 677
[email protected]
Last Updated 03/28/2010
Genetics 677