This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison
Chemical genetics
MPEP
According to NCBI there are no chemical compounds for FMR1 or Fragile X syndrome. However according to the article on msnbc.com a mGluR5 antagonist could be the a novel way to help people restore brain function. I would think that its critical to wait for the full data and article to be published by the team conducting this research. However it might also be interesting to give the drug to developing Danio rerio embryos and see if the insitu-hybridization follows the same patterns as the FMR1 protein.
To the right is the chemical structure of 2-methly-6-pheylethynyl-pyridine, MPEP, a drug used in a few FMR1 Knock-out (KO) mice model studies I've found on pubmed. Links for abstracts for two of these articles can be found as follows: Yuskaitis, CJ et al. 2010. and Westmark, CJ et al. 2009.
To the right is the chemical structure of 2-methly-6-pheylethynyl-pyridine, MPEP, a drug used in a few FMR1 Knock-out (KO) mice model studies I've found on pubmed. Links for abstracts for two of these articles can be found as follows: Yuskaitis, CJ et al. 2010. and Westmark, CJ et al. 2009.
References
[1] NCBI: www.ncbi.nlm.nih.gov/sites/gquery
[2] AP. 2010, Fragile X syndrome could be eased by a pill; researchers work to develop first treatment for genetic learning disorder. http://www.msnbc.msn.com/id/35185356/
[3] Figure: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11245456&loc=ec_rcs
[4] pubmed: http://www.ncbi.nlm.nih.gov/pubmed
[2] AP. 2010, Fragile X syndrome could be eased by a pill; researchers work to develop first treatment for genetic learning disorder. http://www.msnbc.msn.com/id/35185356/
[3] Figure: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11245456&loc=ec_rcs
[4] pubmed: http://www.ncbi.nlm.nih.gov/pubmed
Aime Agather
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Last Updated 05/10/2010
Genetics 677
[email protected]
Last Updated 05/10/2010
Genetics 677