This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison
- Transport
- mRNA transport
Above you will find the two biological processes that FMRP is involved in. It turns out that these two processes are crucial for the development of synapses and the regulation of other protein translation in the synapses of dendrites, which is a molecular function.
The importance of FMRP's transport and regulation of other protein can be seen below in a figure taken from a paper by Westmark and Westmark [3] from the Waisman Center located on the UW-Madison campus. As seen in the figure FMRP, the bright green oval, has a role in moving the APP mRNA from the soma to the spine of the dendrite and preventing the transcription of the mRNA until mGluR5 activates the expression of the mRNA. The box on the left of the figure depicts FXS, constant expression of the APP protein as a result from not being able to repress mRNA translation.
Overall it is intriguing that FMRP is involved in transport especially of mRNA, as the spines of dendrites are the portions of the neurons that receive signals from other neurons. Translation of the many different messages is crucial for brain signaling; and from these G.O. associations and given the figure below it can be inferred that the neuronal signaling is aberrant in FXS patients due to improper transportation of mRNAs.
References
[1] AmiGO: http://amigo.geneontology.org/cgi-bin/amigo/gp-assoc.cgi?gp=UniProtKB/Swiss-Prot:Q06787&session_id=6102amigo1269790532
[2] AmiGO Figures for FMR1
[3] Westmark, C., Westmark, P., Malter, J. (2009) MPEP Reduces Seizure Severity in Fmr-1 KO mice over Expressing Human A. Int J Clin Exp Pathol. 56-68
[2] AmiGO Figures for FMR1
[3] Westmark, C., Westmark, P., Malter, J. (2009) MPEP Reduces Seizure Severity in Fmr-1 KO mice over Expressing Human A. Int J Clin Exp Pathol. 56-68
Aime Agather
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Last Updated 05/16/2010
Genetics 677
[email protected]
Last Updated 05/16/2010
Genetics 677